PoplarV1, Main, Exploration, bibRecord, 000790

Phenolic Compounds from Populus alba L. and Salix subserrata Willd. (Salicaceae) Counteract Oxidative Stress in Caenorhabditis elegans.

Identifieur interne : 000790 ( Main/Exploration ); précédent : 000789; suivant : 000791

Phenolic Compounds from Populus alba L. and Salix subserrata Willd. (Salicaceae) Counteract Oxidative Stress in Caenorhabditis elegans.

Auteurs : Nora Tawfeek [Allemagne, Égypte] ; Mansour Sobeh [Allemagne, Maroc] ; Dalia I. Hamdan [Égypte] ; Nawaal Farrag [Égypte] ; Mariana Roxo [Allemagne] ; Assem M. El-Shazly [Égypte] ; Michael Wink [Allemagne]

Source :

Molecules (Basel, Switzerland) [ 1420-3049 ] ; 2019.

RBID : pubmed:31137712

Descripteurs français

KwdFr :
- Animaux (MeSH), Antioxydants (pharmacologie), Caenorhabditis elegans (effets des médicaments et des substances chimiques), Caenorhabditis elegans (physiologie), Catéchine (analogues et dérivés), Catéchine (pharmacologie), Dérivés du biphényle (composition chimique), Espèces réactives de l'oxygène (métabolisme), Extraits de plantes (pharmacologie), Flavonoïdes (analyse), Phénols (isolement et purification), Phénols (pharmacologie), Picrates (composition chimique), Populus (composition chimique), Produits biologiques (composition chimique), Produits biologiques (isolement et purification), Protéines à fluorescence verte (métabolisme), Redistribution de fluorescence après photoblanchiment (MeSH), Salix (composition chimique), Stress oxydatif (effets des médicaments et des substances chimiques).
MESH :
- analogues et dérivés : Catéchine.
- analyse : Flavonoïdes.
- composition chimique : Dérivés du biphényle, Picrates, Populus, Produits biologiques, Salix.
- effets des médicaments et des substances chimiques : Caenorhabditis elegans, Stress oxydatif.
- isolement et purification : Phénols, Produits biologiques.
- métabolisme : Espèces réactives de l'oxygène, Protéines à fluorescence verte.
- pharmacologie : Antioxydants, Catéchine, Extraits de plantes, Phénols.
- physiologie : Caenorhabditis elegans.
- Animaux, Redistribution de fluorescence après photoblanchiment.

English descriptors

KwdEn :
- Animals (MeSH), Antioxidants (pharmacology), Biological Products (chemistry), Biological Products (isolation & purification), Biphenyl Compounds (chemistry), Caenorhabditis elegans (drug effects), Caenorhabditis elegans (physiology), Catechin (analogs & derivatives), Catechin (pharmacology), Flavonoids (analysis), Fluorescence Recovery After Photobleaching (MeSH), Green Fluorescent Proteins (metabolism), Oxidative Stress (drug effects), Phenols (isolation & purification), Phenols (pharmacology), Picrates (chemistry), Plant Extracts (pharmacology), Populus (chemistry), Reactive Oxygen Species (metabolism), Salix (chemistry).
MESH :
- chemical , analogs & derivatives : Catechin.
- chemical , analysis : Flavonoids.
- chemical , chemistry : Biological Products, Biphenyl Compounds, Picrates.
- chemical , isolation & purification : Biological Products, Phenols.
- chemical , metabolism : Green Fluorescent Proteins, Reactive Oxygen Species.
- chemical , pharmacology : Antioxidants, Catechin, Phenols, Plant Extracts.
- chemistry : Populus, Salix.
- drug effects : Caenorhabditis elegans, Oxidative Stress.
- physiology : Caenorhabditis elegans.
- Animals, Fluorescence Recovery After Photobleaching.

Abstract

Utilizing bioassay- and TLC-guided column chromatography, fifteen secondary metabolites from Populus alba and eight compounds from Salix subserrata were isolated, including a novel plant metabolite salicyl ether and characterized using ultralviolet light (UV) absorbance, mass spectrometry (MS), ¹H-, ¹³C-NMR (nuclear magnetic resonance), heteronuclear single quantum coherence spectroscopy (HSQC) and heteronuclear multiple bond correlation (HMBC). The extracts, their sub-fractions and the isolated compounds exhibited promising antioxidant activities in vitro in DPPH and FRAP assays. Also, the extracts of P. alba leaf (PL), shoots (PS), and S. subserrata leaf (SL) demonstrated substantial antioxidant activities in vivo in the multicellular model organism Caenorhabditis elegans. For the first time, the isolated secondary metabolites, aromadendrin, tremuloidin, salicin, isorhamnetin-3-O-β-d-rutinoside, gallocatechin, triandrin, and chrysoeriol-7-O-glucuronide were investigated. They exhibited substantial antioxidant activities in vivo. Salicin, isorhamnetin-3-O-β-d-rutinoside and gallocatechin, in particular, protected the worms against a lethal dose of the pro-oxidant juglone (80 µM), decreased the endogenous reactive oxygen species (ROS) level to 45.34%, 47.31%, 68.09% and reduced juglone- induced hsp-16.2::GFP (green fluorescence protein) expression to 79.62%, 70.17%, 26.77%, respectively. However, only gallocatechin induced higher levels of sod-3 expression. These findings support the traditional use of Populus alba and Salix subserrata for treating inflammation especially when ROS are involved.

DOI: 10.3390/molecules24101999
PubMed: 31137712
PubMed Central: PMC6571762

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000875
to stream Main, to step Curation: 000875

Le document en format XML

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 L. and <i>Salix subserrata</i>
 Willd. (Salicaceae) Counteract Oxidative Stress in <i>Caenorhabditis elegans</i>
.</title>
<author><name sortKey="Tawfeek, Nora" sort="Tawfeek, Nora" uniqKey="Tawfeek N" first="Nora" last="Tawfeek">Nora Tawfeek</name>
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<country xml:lang="fr">Égypte</country>
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<author><name sortKey="Hamdan, Dalia I" sort="Hamdan, Dalia I" uniqKey="Hamdan D" first="Dalia I" last="Hamdan">Dalia I. Hamdan</name>
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<author><name sortKey="Farrag, Nawaal" sort="Farrag, Nawaal" uniqKey="Farrag N" first="Nawaal" last="Farrag">Nawaal Farrag</name>
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<author><name sortKey="El Shazly, Assem M" sort="El Shazly, Assem M" uniqKey="El Shazly A" first="Assem M" last="El-Shazly">Assem M. El-Shazly</name>
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<author><name sortKey="Wink, Michael" sort="Wink, Michael" uniqKey="Wink M" first="Michael" last="Wink">Michael Wink</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Phenolic Compounds from <i>Populus alba</i>
 L. and <i>Salix subserrata</i>
 Willd. (Salicaceae) Counteract Oxidative Stress in <i>Caenorhabditis elegans</i>
.</title>
<author><name sortKey="Tawfeek, Nora" sort="Tawfeek, Nora" uniqKey="Tawfeek N" first="Nora" last="Tawfeek">Nora Tawfeek</name>
<affiliation wicri:level="3"><nlm:affiliation>Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Im Neuenheimer Feld 364, 69120 Heidelberg, Germany. noratawfeek1@gmail.com.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Im Neuenheimer Feld 364, 69120 Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pharmacognosy, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt. noratawfeek1@gmail.com.</nlm:affiliation>
<country xml:lang="fr">Égypte</country>
<wicri:regionArea>Department of Pharmacognosy, Faculty of Pharmacy, Zagazig University, Zagazig 44519</wicri:regionArea>
<wicri:noRegion>Zagazig 44519</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sobeh, Mansour" sort="Sobeh, Mansour" uniqKey="Sobeh M" first="Mansour" last="Sobeh">Mansour Sobeh</name>
<affiliation wicri:level="3"><nlm:affiliation>Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Im Neuenheimer Feld 364, 69120 Heidelberg, Germany. sobeh@uni-heidelberg.de.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Im Neuenheimer Feld 364, 69120 Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>AgroBioSciences Research Division, Mohammed VI Polytechnic University, Lot 660-Hay MoulayRachid, 43150 Ben-Guerir, Morocco. sobeh@uni-heidelberg.de.</nlm:affiliation>
<country xml:lang="fr">Maroc</country>
<wicri:regionArea>AgroBioSciences Research Division, Mohammed VI Polytechnic University, Lot 660-Hay MoulayRachid, 43150 Ben-Guerir</wicri:regionArea>
<wicri:noRegion>43150 Ben-Guerir</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hamdan, Dalia I" sort="Hamdan, Dalia I" uniqKey="Hamdan D" first="Dalia I" last="Hamdan">Dalia I. Hamdan</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pharmacognosy, Faculty of Pharmacy, Menoufia University, Shibin Elkom 32511, Egypt. dalia_hamdan@yahoo.com.</nlm:affiliation>
<country xml:lang="fr">Égypte</country>
<wicri:regionArea>Department of Pharmacognosy, Faculty of Pharmacy, Menoufia University, Shibin Elkom 32511</wicri:regionArea>
<wicri:noRegion>Shibin Elkom 32511</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Farrag, Nawaal" sort="Farrag, Nawaal" uniqKey="Farrag N" first="Nawaal" last="Farrag">Nawaal Farrag</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pharmacognosy, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt. nawalfarrag@yahoo.com.</nlm:affiliation>
<country xml:lang="fr">Égypte</country>
<wicri:regionArea>Department of Pharmacognosy, Faculty of Pharmacy, Zagazig University, Zagazig 44519</wicri:regionArea>
<wicri:noRegion>Zagazig 44519</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Roxo, Mariana" sort="Roxo, Mariana" uniqKey="Roxo M" first="Mariana" last="Roxo">Mariana Roxo</name>
<affiliation wicri:level="3"><nlm:affiliation>Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Im Neuenheimer Feld 364, 69120 Heidelberg, Germany. marianaroxocorreia@gmail.com.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Im Neuenheimer Feld 364, 69120 Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="El Shazly, Assem M" sort="El Shazly, Assem M" uniqKey="El Shazly A" first="Assem M" last="El-Shazly">Assem M. El-Shazly</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pharmacognosy, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt. assemels2002@yahoo.co.uk.</nlm:affiliation>
<country xml:lang="fr">Égypte</country>
<wicri:regionArea>Department of Pharmacognosy, Faculty of Pharmacy, Zagazig University, Zagazig 44519</wicri:regionArea>
<wicri:noRegion>Zagazig 44519</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wink, Michael" sort="Wink, Michael" uniqKey="Wink M" first="Michael" last="Wink">Michael Wink</name>
<affiliation wicri:level="3"><nlm:affiliation>Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Im Neuenheimer Feld 364, 69120 Heidelberg, Germany. wink@uni-heidelberg.de.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Im Neuenheimer Feld 364, 69120 Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
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<series><title level="j">Molecules (Basel, Switzerland)</title>
<idno type="eISSN">1420-3049</idno>
<imprint><date when="2019" type="published">2019</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term>
<term>Antioxidants (pharmacology)</term>
<term>Biological Products (chemistry)</term>
<term>Biological Products (isolation & purification)</term>
<term>Biphenyl Compounds (chemistry)</term>
<term>Caenorhabditis elegans (drug effects)</term>
<term>Caenorhabditis elegans (physiology)</term>
<term>Catechin (analogs & derivatives)</term>
<term>Catechin (pharmacology)</term>
<term>Flavonoids (analysis)</term>
<term>Fluorescence Recovery After Photobleaching (MeSH)</term>
<term>Green Fluorescent Proteins (metabolism)</term>
<term>Oxidative Stress (drug effects)</term>
<term>Phenols (isolation & purification)</term>
<term>Phenols (pharmacology)</term>
<term>Picrates (chemistry)</term>
<term>Plant Extracts (pharmacology)</term>
<term>Populus (chemistry)</term>
<term>Reactive Oxygen Species (metabolism)</term>
<term>Salix (chemistry)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux (MeSH)</term>
<term>Antioxydants (pharmacologie)</term>
<term>Caenorhabditis elegans (effets des médicaments et des substances chimiques)</term>
<term>Caenorhabditis elegans (physiologie)</term>
<term>Catéchine (analogues et dérivés)</term>
<term>Catéchine (pharmacologie)</term>
<term>Dérivés du biphényle (composition chimique)</term>
<term>Espèces réactives de l'oxygène (métabolisme)</term>
<term>Extraits de plantes (pharmacologie)</term>
<term>Flavonoïdes (analyse)</term>
<term>Phénols (isolement et purification)</term>
<term>Phénols (pharmacologie)</term>
<term>Picrates (composition chimique)</term>
<term>Populus (composition chimique)</term>
<term>Produits biologiques (composition chimique)</term>
<term>Produits biologiques (isolement et purification)</term>
<term>Protéines à fluorescence verte (métabolisme)</term>
<term>Redistribution de fluorescence après photoblanchiment (MeSH)</term>
<term>Salix (composition chimique)</term>
<term>Stress oxydatif (effets des médicaments et des substances chimiques)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Catechin</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Flavonoids</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Biological Products</term>
<term>Biphenyl Compounds</term>
<term>Picrates</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="isolation & purification" xml:lang="en"><term>Biological Products</term>
<term>Phenols</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Green Fluorescent Proteins</term>
<term>Reactive Oxygen Species</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antioxidants</term>
<term>Catechin</term>
<term>Phenols</term>
<term>Plant Extracts</term>
</keywords>
<keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>Catéchine</term>
</keywords>
<keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Flavonoïdes</term>
</keywords>
<keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Populus</term>
<term>Salix</term>
</keywords>
<keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Dérivés du biphényle</term>
<term>Picrates</term>
<term>Populus</term>
<term>Produits biologiques</term>
<term>Salix</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Caenorhabditis elegans</term>
<term>Oxidative Stress</term>
</keywords>
<keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Caenorhabditis elegans</term>
<term>Stress oxydatif</term>
</keywords>
<keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Phénols</term>
<term>Produits biologiques</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Espèces réactives de l'oxygène</term>
<term>Protéines à fluorescence verte</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antioxydants</term>
<term>Catéchine</term>
<term>Extraits de plantes</term>
<term>Phénols</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Caenorhabditis elegans</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Caenorhabditis elegans</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Fluorescence Recovery After Photobleaching</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Redistribution de fluorescence après photoblanchiment</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Utilizing bioassay- and TLC-guided column chromatography, fifteen secondary metabolites from <i>Populus alba</i>
 and eight compounds from <i>Salix subserrata</i>
 were isolated, including a novel plant metabolite salicyl ether and characterized using ultralviolet light (UV) absorbance, mass spectrometry (MS), <sup>1</sup>
H-, <sup>13</sup>
C-NMR (nuclear magnetic resonance), heteronuclear single quantum coherence spectroscopy (HSQC) and heteronuclear multiple bond correlation (HMBC). The extracts, their sub-fractions and the isolated compounds exhibited promising antioxidant activities in vitro in DPPH and FRAP assays. Also, the extracts of <i>P. alba</i>
 leaf (PL), shoots (PS), and <i>S. subserrata</i>
 leaf (SL) demonstrated substantial antioxidant activities in vivo in the multicellular model organism <i>Caenorhabditis elegans</i>
. For the first time, the isolated secondary metabolites, aromadendrin, tremuloidin, salicin, isorhamnetin-3-<i>O</i>
-β-d-rutinoside, gallocatechin, triandrin, and chrysoeriol-7-<i>O</i>
-glucuronide were investigated. They exhibited substantial antioxidant activities in vivo. Salicin, isorhamnetin-3-<i>O</i>
-β-d-rutinoside and gallocatechin, in particular, protected the worms against a lethal dose of the pro-oxidant juglone (80 µM), decreased the endogenous reactive oxygen species (ROS) level to 45.34%, 47.31%, 68.09% and reduced juglone- induced hsp-16.2::GFP (green fluorescence protein) expression to 79.62%, 70.17%, 26.77%, respectively. However, only gallocatechin induced higher levels of sod-3 expression. These findings support the traditional use of <i>Populus alba</i>
 and <i>Salix subserrata</i>
 for treating inflammation especially when ROS are involved.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">31137712</PMID>
<DateCompleted><Year>2019</Year>
<Month>11</Month>
<Day>21</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>02</Month>
<Day>25</Day>
</DateRevised>
<Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1420-3049</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>24</Volume>
<Issue>10</Issue>
<PubDate><Year>2019</Year>
<Month>May</Month>
<Day>24</Day>
</PubDate>
</JournalIssue>
<Title>Molecules (Basel, Switzerland)</Title>
<ISOAbbreviation>Molecules</ISOAbbreviation>
</Journal>
<ArticleTitle>Phenolic Compounds from <i>Populus alba</i>
 L. and <i>Salix subserrata</i>
 Willd. (Salicaceae) Counteract Oxidative Stress in <i>Caenorhabditis elegans</i>
.</ArticleTitle>
<ELocationID EIdType="pii" ValidYN="Y">E1999</ELocationID>
<ELocationID EIdType="doi" ValidYN="Y">10.3390/molecules24101999</ELocationID>
<Abstract><AbstractText>Utilizing bioassay- and TLC-guided column chromatography, fifteen secondary metabolites from <i>Populus alba</i>
 and eight compounds from <i>Salix subserrata</i>
 were isolated, including a novel plant metabolite salicyl ether and characterized using ultralviolet light (UV) absorbance, mass spectrometry (MS), <sup>1</sup>
H-, <sup>13</sup>
C-NMR (nuclear magnetic resonance), heteronuclear single quantum coherence spectroscopy (HSQC) and heteronuclear multiple bond correlation (HMBC). The extracts, their sub-fractions and the isolated compounds exhibited promising antioxidant activities in vitro in DPPH and FRAP assays. Also, the extracts of <i>P. alba</i>
 leaf (PL), shoots (PS), and <i>S. subserrata</i>
 leaf (SL) demonstrated substantial antioxidant activities in vivo in the multicellular model organism <i>Caenorhabditis elegans</i>
. For the first time, the isolated secondary metabolites, aromadendrin, tremuloidin, salicin, isorhamnetin-3-<i>O</i>
-β-d-rutinoside, gallocatechin, triandrin, and chrysoeriol-7-<i>O</i>
-glucuronide were investigated. They exhibited substantial antioxidant activities in vivo. Salicin, isorhamnetin-3-<i>O</i>
-β-d-rutinoside and gallocatechin, in particular, protected the worms against a lethal dose of the pro-oxidant juglone (80 µM), decreased the endogenous reactive oxygen species (ROS) level to 45.34%, 47.31%, 68.09% and reduced juglone- induced hsp-16.2::GFP (green fluorescence protein) expression to 79.62%, 70.17%, 26.77%, respectively. However, only gallocatechin induced higher levels of sod-3 expression. These findings support the traditional use of <i>Populus alba</i>
 and <i>Salix subserrata</i>
 for treating inflammation especially when ROS are involved.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Tawfeek</LastName>
<ForeName>Nora</ForeName>
<Initials>N</Initials>
<AffiliationInfo><Affiliation>Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Im Neuenheimer Feld 364, 69120 Heidelberg, Germany. noratawfeek1@gmail.com.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Pharmacognosy, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt. noratawfeek1@gmail.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sobeh</LastName>
<ForeName>Mansour</ForeName>
<Initials>M</Initials>
<Identifier Source="ORCID">0000-0002-2719-8534</Identifier>
<AffiliationInfo><Affiliation>Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Im Neuenheimer Feld 364, 69120 Heidelberg, Germany. sobeh@uni-heidelberg.de.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>AgroBioSciences Research Division, Mohammed VI Polytechnic University, Lot 660-Hay MoulayRachid, 43150 Ben-Guerir, Morocco. sobeh@uni-heidelberg.de.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hamdan</LastName>
<ForeName>Dalia I</ForeName>
<Initials>DI</Initials>
<Identifier Source="ORCID">0000-0003-3057-4702</Identifier>
<AffiliationInfo><Affiliation>Department of Pharmacognosy, Faculty of Pharmacy, Menoufia University, Shibin Elkom 32511, Egypt. dalia_hamdan@yahoo.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Farrag</LastName>
<ForeName>Nawaal</ForeName>
<Initials>N</Initials>
<AffiliationInfo><Affiliation>Department of Pharmacognosy, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt. nawalfarrag@yahoo.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Roxo</LastName>
<ForeName>Mariana</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Im Neuenheimer Feld 364, 69120 Heidelberg, Germany. marianaroxocorreia@gmail.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>El-Shazly</LastName>
<ForeName>Assem M</ForeName>
<Initials>AM</Initials>
<AffiliationInfo><Affiliation>Department of Pharmacognosy, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt. assemels2002@yahoo.co.uk.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wink</LastName>
<ForeName>Michael</ForeName>
<Initials>M</Initials>
<Identifier Source="ORCID">0000-0002-7875-4510</Identifier>
<AffiliationInfo><Affiliation>Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Im Neuenheimer Feld 364, 69120 Heidelberg, Germany. wink@uni-heidelberg.de.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2019</Year>
<Month>05</Month>
<Day>24</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>Switzerland</Country>
<MedlineTA>Molecules</MedlineTA>
<NlmUniqueID>100964009</NlmUniqueID>
<ISSNLinking>1420-3049</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000975">Antioxidants</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D001688">Biological Products</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D001713">Biphenyl Compounds</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D005419">Flavonoids</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D010636">Phenols</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D010851">Picrates</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D010936">Plant Extracts</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D017382">Reactive Oxygen Species</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>147336-22-9</RegistryNumber>
<NameOfSubstance UI="D049452">Green Fluorescent Proteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>8R1V1STN48</RegistryNumber>
<NameOfSubstance UI="D002392">Catechin</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>BQM438CTEL</RegistryNumber>
<NameOfSubstance UI="C045651">epigallocatechin gallate</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>DFD3H4VGDH</RegistryNumber>
<NameOfSubstance UI="C004931">1,1-diphenyl-2-picrylhydrazyl</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000975" MajorTopicYN="N">Antioxidants</DescriptorName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001688" MajorTopicYN="N">Biological Products</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
<QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001713" MajorTopicYN="N">Biphenyl Compounds</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017173" MajorTopicYN="N">Caenorhabditis elegans</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
<QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002392" MajorTopicYN="N">Catechin</DescriptorName>
<QualifierName UI="Q000031" MajorTopicYN="N">analogs & derivatives</QualifierName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005419" MajorTopicYN="N">Flavonoids</DescriptorName>
<QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D036681" MajorTopicYN="N">Fluorescence Recovery After Photobleaching</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D049452" MajorTopicYN="N">Green Fluorescent Proteins</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018384" MajorTopicYN="Y">Oxidative Stress</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010636" MajorTopicYN="N">Phenols</DescriptorName>
<QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName>
<QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010851" MajorTopicYN="N">Picrates</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010936" MajorTopicYN="N">Plant Extracts</DescriptorName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D032107" MajorTopicYN="N">Populus</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017382" MajorTopicYN="N">Reactive Oxygen Species</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D032108" MajorTopicYN="N">Salix</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Caenorhabditis elegans</Keyword>
<Keyword MajorTopicYN="N">Populus alba</Keyword>
<Keyword MajorTopicYN="N">Salix subserrata</Keyword>
<Keyword MajorTopicYN="N">oxidative stress</Keyword>
</KeywordList>
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<Day>10</Day>
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<Month>05</Month>
<Day>20</Day>
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Phenolic Compounds from Populus alba L. and Salix subserrata Willd. (Salicaceae) Counteract Oxidative Stress in Caenorhabditis elegans.

Phenolic Compounds from Populus alba L. and Salix subserrata Willd. (Salicaceae) Counteract Oxidative Stress in Caenorhabditis elegans.

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